Dec 03, 2024  
2024-2025 Undergraduate Catalog 
    
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2024-2025 Undergraduate Catalog

BI 318 Human Genome and Disease

(4 Credits)
This is an interdisciplinary course that explores the role of the human genome in the development of disease.  This course commences with a survey of modes of inheritance and gene-environment interactions that contribute to phenotypic outcomes. Types of mutations in the genetic code, both germline and somatic, will be discussed and case studies will be used to illustrate the impact of these alterations on disease initiation and/or progression.   This course will also explore the effects of epigenetic modifications to the human genome that result in changes to gene expression.  Both programmed and environmentally induced epigenetic changes will be considered for their role in development, disease, and aging.  The course will conclude with a module in genomics that includes a discussion of initiatives including The Human Genome Project, 1000 Genomes Project, and the HapMap Project.  Students will formulate hypotheses related to genetic variation or mutation and the disease state, and test hypotheses using genome databases, cloud computing services, and bioinformatic tools.

 

Three lecture hours weekly

Prerequisite: BI 101 , BI 102 , BI 204 , BI 242  or permission of the Department Chair